Labs

Ishibashi Laboratory

About the Lab

Many children with congenital heart disease, particularly the most complex anomalies, suffer from important behavioral anomalies and neurodevelopmental delay after surgical correction of their anomaly. Our research activities focus on studying how congenital heart disease and subsequent cardiac surgery affect the rapidly developing brain in fetal, neonatal and infant populations. We have successfully utilized sophisticated and cutting-edge neuroscience approaches in several clinically relevant experimental models of injury. The long-term goal of our research program is to optimize treatment strategy and develop new approaches that will reduce neurodevelopmental impairment in children with congenital heart disease.

Featured Publications

  • Mesenchymal stromal cell delivery via cardiopulmonary bypass provides neuroprotection in a juvenile porcine surgical model

    Sarkislali K, Kobayashi K, Saric N, Maeda T, Somaa FA, Bansal A, Tu SC, Ayodeji MA, Leonetti C, Hsu C, Li J, Vyas P, Kawasawa YI, Tu TW, Wang PC, Hanley PJ, Hashimoto-Torii K, Frank JA, Jonas RA, Ishibashi N. J Am Coll Cardiol Basic Trans Science Epublished DOI: 10.1016/j.jacbts.2023.07.002 September (2023)

  • Non-apoptotic caspases in neural development and in anesthesia-induced neurotoxicity

    Sarić N, Hashimoto-Torii K, Jevtovic-Todorovic V, Ishibashi N. DOI: 10.1016/j.tins.2022.03.007 PMID: 35491256 Trends Neurosci. 45(6):446-458 June (2022)

  • Impact of Cardiopulmonary Bypass on Neurogenesis and Cortical Maturation

    Dhari Z, Leonetti C, Lin S, Prince A, Howick J, Zurakowski D, Wang PC, Jonas RA, Ishibashi N. doi: 10.1002/ana.26235 Ann Neurol. Vol. 90 Issue 6 Pages 913-926 (2021)

  • Cortical dysmaturation in congenital heart disease

    Leonetti C, Back SA, Gallo V, Ishibashi N PMID: 30616953 Trends Neurosci January (2019)

  • Abnormal neurogenesis and cortical growth in congenital heart disease

    Morton PD, Korotcova L, Lewis BK, Bhuvanendran S, Ramachandra SD, Zurakowski D, Zhang J, Mori S, Frank JA, Jonas, RA, Gallo V, Ishibashi N PMID: 28123074 Sci Transl Med 25;9 January (2017)
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Related News
  • Innovation District

U.S. DoD awards $2M for study to protect neurological function after cardiac surgery

July 02, 2020

The U.S. DoD has awarded $2 million to Children’s to study how a family of protease enzymes known as caspases may contribute to brain cell degeneration.

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