Labs

Haydar Laboratory

The Haydar Laboratory is focused on forebrain development and function. A major focus is the study of how forebrain stem and progenitor cells generate the extraordinary level of neuronal diversity and circuit complexity during development. We are particularly interested in how brain development is modified in developmental disorders such as Down syndrome, epilepsy and autism, and are exploring how the hundreds of triplicated genes in Down syndrome lead to motor dysfunction and intellectual disability. 

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Featured Publications

  • Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome

    Shaw, P.R., Klein, J.A., Aziz, N.M. and Haydar T.F. Dis. Model. Mech dmm.046243. doi:10.1242/dmm.046243. August (2020)

  • Distinct neocortical progenitor lineages fine-tune neuronal diversity in a layer-specific manner

    Guillamon-Vivancos, T., Tyler, W.A., Medalla, M., Chang, W.W., Okamoto, M., Haydar, T.F.* and Luebke, J.I. Cerebral Cortex 29(3):1121-1138 March (2019)

  • CLASP2 links Reelin to the cytoskeleton during neocortical development

    Dillon, G.M.*, Tyler, W.A.*, Omuro, K.C., Kambouris, J., Tyminski, C., Henry, S., Haydar, T.F., Beffert, U., Ho, A Neuron 93(6): 1344-135 (2017)

  • Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination

    Olmos-Serrano, J.L.1, Kang, H.J.1, Tyler, W.A.1, Cheng, F.1, Zhu, Y., Silbereis, J.C., Pletikos, M., Jankovic-Rapan, L., Cramer, N.P., Galdzicki, Z., Goodliffe, J., Peters, A., Sethares, C., Haydar, T.F.* and Sestan, N. Neuron 89: 1-15 (2016)

  • Absence of prenatal forebrain defects in the Dp(16)1Yey/+ mouse model of Down syndrome

    Goodliffe, J.W., Olmos-Serrano, J.L., Aziz, N.M., Pennings, J.L., Guedj, F., Bianchi, D.W. and Haydar, T.F. Journal of Neuroscience 36(10):2926-44 (2016)
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