Labs
Li Laboratory
About the Lab
The Li lab uses the latest gene editing technology (including CRISPR-Cas9 and CRISPR-Cas9 screening) and new computational algorithms to better understand how coding and non-coding elements function in human physiology and disease, and to further identify novel molecular targets to inform precision medicine. We are particularly interested in applying new computer science, artificial intelligence, and machine learning methods to address challenges in biomedical and biological big data problems. More information can be found on the Li lab website.
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Lab Focus Areas
Cancer Biology and Experimental Cancer Therapy
Genetic Determinants of Risk and Response to Therapy -
Contact
Wei Li, Ph.D. Principal Investigator wli2@childrensnational.org
- External Lab Site
Featured Publications
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Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches
Xiaolong Cheng*, Zexu Li*, Ruocheng Shan, Zihan Li, Lumen Chao, Jian Peng, Teng Fei#, Wei Li# deepcas13.weililab.org/ bioRxiv 2021 -
CRISP-view: a database of functional genetic screens spanning multiple phenotypes
Yingbo Cui*, Xiaolong Cheng*, Qing Chen, Bicna Song, Anthony Chiu, Yuan Gao, Tyson Dawson, Lumen Chao, Wubing Zhang, Dian Li, Zexiang Zeng, Jijun Yu, Zexu Li, Teng Fei, Shaoliang Peng, Wei Li# crispview.weililab.org Nucleic Acids Research 49 (D1) D848-854 2021 -
Linking genotypes with multiple phenotypes in single-cell CRISPR screens
Lin Yang*, Yuqing Zhu*, Hua Yu*, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang#, Wei Li# bitbucket.org/weililab/scmageck/src/master/ Genome Biology 21, 19 2021 -
Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute
Binbin Wang*, Mei Wang*, Wubing Zhang*, Tengfei Xiao, Chen-Hao Chen, Alexander Wu, Feizhen Wu, Nicole Traugh, Xiaoqing Wang, Ziyi Li, Shenglin Mei, Yingbo Cui, Sailing Shi, Jesse Jonathan Lipp, Matthias Hinterndorfer, Johannes Zuber, Myles Brown, Wei Li#, X. Shirley Liu# Nature Protocols (14) 756-780 2019 -
MAGeCK enables robust identification of essential genes from genome-scale CRISPR-Cas9 knockout screens
Wei Li*, Han Xu*, Tengfei Xiao, Le Cong, Feng Zhang, Jun S. Liu, Myles Brown, X. Shirley Liu sourceforge.net/projects/mageck/ Genome Biology 15:554 2014