Funding

The Zohn Laboratory is primarily funded by federal grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Current Funding 

R01HD098861 - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 

Title: "Regulation of Cranial Mesenchyme Expansion Driving Neural Fold Elevation"

Role: Principal Investigator

The goal of this project is to elucidate the molecular and cellular mechanisms underlying neural tube defects utilizing a model of neural tube defects with a failure of cranial mesenchyme expansion and neural fold elevation. 

R01HD098861-01A1S1 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 

Title: "Diversity Supplement to Regulation of Cranial Mesenchyme Expansion Driving Neural Fold Elevation"

Role: Mentor

The goal of this administrative supplement is to provide post-baccalaureate training opportunities for a trainee.

Past Funding

R01HD092593 - NICHD

Title:  "Novel roles of Placental Allopregnanone in Brain Development and Injury"

Role: Co-Investigator

The goal of this project is to evaluate the importance of placental hormones in brain development.

F31HD098886  - NICHD

Title: "Placental Allopregnanolone is Essential for Development of Cortical Gabaergic Signaling"

Role: Co-Mentor

The goal of this predoctoral fellowship is to provide support for a graduate student.

P01HD083157 - NICHD

Title: "Pathology, Developmental Origins and Prevention of Pediatric Dysphagia"

Role: Principal Investigator

The goal of project III of this program project grant is to determine the effect of periconception micronutrient exposure on the penetrance and severity of pediatric dysphagia in a mouse model of DiGeorge syndrome. 

P01HD083157 01A1S1 - NICHD

Title: Diversity Supplement to "Pathology, Developmental Origins and Prevention of Pediatric Dysphagia"

Role: Co-Mentor

The goal of this administrative supplement is to provide post-baccalaureate training opportunities for a student. 

R21HD090623 - NICHD

Title: "Gene-environment interactions resulting in neural tube defects with 22q11 deletions"

Role: Principal Investigator

The goal of this project is to determine the mechanism underlying altered buffering of environment perturbations in a mouse model of DiGeorge syndrome. Experiments will focus on the hypothesis that altered miRNA processing underlies the increased susceptibility of 22q11 mutant embryos for neural tube defects.

R21HD076202 - NICHD

Title: "Iron Deficiency and Neural Tube Defects"

Role: Principal Investigator

The goal of this study is to provide the first evidence of the utility of iron in combination with folic acid in the prevention of neural tube defects and to elucidate the mechanistic pathways by which deficiency of this important nutrient leads to birth defects.

R01HD058629 - NICHD

Title: "Novel Ubiquitin Dependent Pathways Regulating Neural Tube Closure and Placentation"

Role: Principal Investigator

The goal of this study is to identify substrates of the Hectd1 ubiquitin ligase to elucidate the mechanism of neural tube and placental defects in the Hectd1opm mutant mouse line.

Basil O’Connor Starter Scholar Research Award - The March of Dimes

Title: "Molecular Mechanisms Causing Spina Bifida and Exencephaly in p38IP-Mutant Embryos"

Role: Principal Investigator

The goal of this study was to investigate the hypothesis that abnormal mesoderm development contributes to neural tube defects.

Young Investigator Award - Spina Bifida Association 

Title: "Molecular Mechanisms Causing Spina Bifida in p38IP-Mutant Embryos"

Role: Principal Investigator

The goal of this study was to investigate the hypothesis that abnormal mesoderm development underlies spina bifida in a mouse model.