Labs
Freishtat Laboratory
About the Lab
The Freishtat Laboratory, also known as the Intercellular Communication in Organ Injury and Repair Laboratory, investigates the role of intercellular communication at a distance in organ injury and repair. We study this communication in several diseases including asthma, diabetes, obesity, Alzheimer’s disease and sepsis. Much of this work focuses on the role of small extracellular vesicles in intercellular communication.
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Lab Focus Areas
Airway Biology Asthma Diabetes Intercellular Communication Neurodegenerative Diseases Non-communicable Diseases Obesity Small Extracellular Vesicles Sepsis
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Contact
Robert Freishtat, M.D. Principal Investigator rfreishtat@childrensnational.org
Featured Publications
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In infants with severe bronchiolitis: Dual-transcriptomic profiling of nasopharyngeal microbiome and host response
Fujiogi M, Camargo CA Jr, Bernot JP, Freishtat RJ, Harmon B, Mansbach JM, Castro-Nallar E, Pérez-Losada M, Hasegawa K PubMed PMID: 31905367 Pediatr Res January (2020) -
Cholesterol efflux alterations in adolescent obesity: Role of adipose-derived extracellular vesical microRNAs
Barberio MD, Kasselman LJ, Playford MP, Epstein SB, Renna HA, Goldberg M, DeLeon J, Voloshyna I, Barlev A, Salama M, Ferrante SC, Nadler EP, Mehta N, Reiss AB, Freishtat RJ PubMed PMID: 31331347; PubMed Central PMCID: PMC6647309. J Transl Med 17(1):232 July (2019) -
Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas
Pérez-Losada M, Authelet KJ, Hoptay CE, Kwak C, Crandall KA, Freishtat RJ PubMed PMID: 30286807; PubMed Central PMCID: PMC6172741. Microbiome 6(1):179 October (2018) -
Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease
Ferrante SC, Nadler EP, Pillai DK, Hubal MJ, Wang Z, Wang JM, Gordish-Dressman H, Koeck E, Sevilla S, Wiles AA, Freishtat RJ PubMed PMID: 25518011; PubMed Central PMCID: PMC4346410. Pediatr Res 77(3):447-54 March (2015) -
Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade
Sharron M, Hoptay CE, Wiles AA, Garvin LM, Geha M, Benton AS, Nagaraju K, Freishtat RJ PubMed PMID: 22844498; PubMed Central PMCID: PMC3406039. PLoS One 7(7):e41549 (2012)